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Nick and Audrey Spitz, are now full-time private detectives after their high profile success 4 years ago. But they find their agency struggling after several failed cases. Turns out, they're not actually very good. One night, while debating their future, they receive an unexpected invitation to a lavish wedding on a private island from their rapper friend from the first movie.
During the ceremony, Audrey spots a cloaked figure trailing Vikram’s elephant. Suddenly, Vik’s bodyguard Lou falls dead from the elephant. Nick suspects it's a distraction and soon witnesses Vik’s kidnapping by a masked figure who escapes by boat. The couple figures there must be two baddies: one to create the diversion and another to execute the abduction.
The next day, a team of elite investigators led by former MI6 hostage negotiator, and Audrey's personal hero, Connor Miller arrives.
The kidnapper calls and demands $70 million. In Paris, Nick and Audrey accompany Miller to the meeting point but are ambushed and forced into a van. A scuffle leads to a crash, and the kidnappers frame the couple. Miller appears to die in a car explosion, but a mysterious thief snatches the briefcase, only to be killed by a second assailant in a garbage truck who steals the money.
The duo arranges a final confrontation at the Eiffel Tower. Vik arrives strapped with a bomb, but Nick assumes that the real mastermind wouldn’t endanger the ransom. Miller reappears, revealing he faked his death.
After Audrey is pulled to the top floor in a struggle, Nick follows, defeats Miller’s henchmen, and destroys the bomb’s detonator.
Miller throws Audrey off the tower while tethered to his harness. Audrey survives, and together they tie Miller’s harness to the elevator system, hurling him into his own helicopter’s blades, which crashes into the river.
Back at the restaurant, Audrey notices that Saira’s smeared henna contradicts her earlier claim, realizing she’s the second conspirator. Saira had previously tried to kill Vik in Mumbai out of jealousy over their family business. She attempts to shoot Vik, but the bodyguard takes the bullet, and Saira get knocked out with the briefcase.
After the chaos, Vik and Claudette elope and gift Nick and Audrey $10 million plus a helicopter. But during their honeymoon flight over Greece, their pilot pulls a gun, reveals himself as American, steals the money, and jumps, leaving the couple to fight for control midair.